Poor solubility of new drugs and their related low oral bioavailability and general delivery problems are becoming a major challenge. Nanosuspensions are a “universal” type of formulation for these molecules and are reviewed in this paper regarding their methods of preparation and the recent advancements in the various top down and bottom up approaches. This review has been performed with particular emphasis on the advancement in the different techniques of preparation of nanosuspensions and the drugs under investigation. Special focus has also been made in the use of stabilizer and advancement in the scale up techniques.
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